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However, no clinical trials have been reported that provide any evidence of its effectiveness for raising the chronically low homeostatic level of glutathione that occurs in primary mitochondrial diseases [1, 11]

Reviewers have repeatedly noted the need for randomized controlled trials before any therapeutic claim can be supported [12]

The inclusion criteria included publications published in the previous decade, and the search approach was iterative, with continual refinement based on the identified literature until a thorough selection of relevant studies was obtained

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