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Key insights from the review: Rapid growth of the field since 2019, led by the US, China, and Germany Strong focus on #stroke, #Alzheimers disease, #Parkinsons disease, and bioactive compounds from traditional Chinese medicine Identification of core molecular hubs: STAT3, IL6, TP53, AKT1, and JUN Major mechanistic hotspots include apoptosis, NLRP3 inflammasome, microglial polarization, and NF-B/JAK-STAT/PI3K-AKT pathways Why it matters The analysis highlights a paradigm shift away from one drugone target approaches toward multi-target, systems-level therapeutic strategies, better aligned with the multifactorial nature of neuroinflammatory CNS diseases

Key results: 12 mg dose: Average weight loss of 24.2 percent of body weight 8 mg dose: Average weight loss of 22.8 percent 4 mg dose: Average weight loss of 17.0 percent Over 90 percent of participants at 8 or 12 mg lost at least 10 percent of body weight Over 75 percent at 12 mg lost at least 20 percent Crucially, the weight loss curve had not yet plateaued at 48 weeks, suggesting longer treatment may produce even greater results

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So far it works the way it says it will

Vomiting and diarrhoea can lead to dehydration, especially if symptoms continue for more than a short period

10.1042/bst20230122 140 ZwebenJ