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Proceedings of the National Academy of Sciences of the United States of America, 108 (52), 2106921074

The critical role of NAD + pool in tumorigenesis NAD + not only acts as a co-enzyme for metabolic redox reactions, but also functions as a co-substrate to modulate the activity of NAD + -consuming enzymes that govern the critical steps in tumorigenesis, including genome stability, metabolism, cell growth, cell death, redox homeostasis and immune response

Elderly Individuals : Older adults often have decreased stomach acid production, which can lead to reduced B12 absorption