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If these symptoms are severe or persistent, your doctor may decide to maintain your current dose longer before increasing, or determine that your current dose represents your optimal maintenance level

Key Takeaways Semaglutide can make you tired and cause fatigue, especially when your body is first adjusting to this class of weight loss medications

Your body produces this compound in the liver and kidneys, and it helps transport fatty acids into mitochondria where they're converted into usable energy for cellular functions

You might be struggling with weight loss even after exercising and eating healthy

Common side effects include nausea, vomiting, diarrhea, and constipation, which typically improve as your body adjusts to treatment

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