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Research indicates that individuals losing weight without sufficient protein may lose a higher proportion of muscle tissue rather than fat, which can reduce resting metabolic rate and impair long-term weight maintenance

At the end of the trial, the patients who received semaglutide had lost an average of 14.9% of their body weight while the placebo group had only lost 2.4%, demonstrating an enormous beneficial impact of semaglutide on weight loss

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Appetite and behavior changes

That translated to roughly 47% greater weight loss with tirzepatide

After that, increases are made in 2.5 mg steps only after at least four weeks on the current dose