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Tretinoin, niacinamide, estriol, and GHK-Cu all have extensive safety data for long-term topical application

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52 ZhangZ.LiuY.HuangQ.SuY.ZhangY.WangG.et al (2014)

Subsequent research has confirmed that copper peptides can extend the anagen phase and improve hair density, with some studies showing comparable or superior results to 5% minoxidil without the initial shedding phase many patients experience with minoxidil

Bypassing it does not make the product safer