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In addition, the SUSTAIN 6 trial demonstrated a significant reduction in major CV events with semaglutide versus placebo in patients with T2D at high CV risk

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Sirtuin-1 plays a positive role in regulating endothelium-dependent vasodilation via the deacetylation of lysines 496 and 506 on endothelial nitric oxide synthase (eNOS) (180)

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Many thanks also go to Bernard Thorens, Richard DiMarchi, Lotte Knudsen, John Eng, Jean-Pierre Raufman, Richard Goodman, Catherine rskov, Matthias Tschp, Daniel Drucker, Jesper Lau and Fred Cowan for their comments on various sections and providing permission to use their photos