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Within the rheumatoid arthritis joint cavity, O 2 produced by synovial fibroblasts oxidizes cysteine 645 of protein-arginine deiminase (PAD)

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The LEADER trial (liraglutide, N=9,340) and SUSTAIN-6 (semaglutide, N=3,297) did not show a statistically significant increase in pancreatitis versus placebo [13,14]