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It has undergone a lot of clinical testing (the STEP trial program included more than 4,500 people) that shows it works and is safe, which supports regulatory submissions in big countries

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The most common downsides of tirzepatide include nausea, constipation, diarrhea, fatigue, bloating, and appetite suppression that may become too strong for some people

ASO economics are an order of magnitude thinner than fully-insured economics

So, in terms of energy, we sometimes we have unrealistic energy expectations