This increase was weaker than that observed with fdx-2 or lias-1 knockdown in wild-type and slcr-46.1 mutant worms, indicating that partial loss of copper transport or binding capacity alone is insufficient to suppress cuproptosis
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Thus, diet supplementation with l-Cys restores the synthesis of glutathione in cases in which it has been compromised, thus improving the redox balance and promoting the reduction of oxidative stress