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Peer review Peer review information Nature Chemistry thanks the anonymous reviewers for their contribution to the peer review of this work

Among them, heme, being essential for all oxygen-demanding organisms, is synthesized from protoporphyrin IX and ferrous ions [11]

This aligns with the contention that this tissue exhibits an energy-replete cardiac state

The authors identified a protective effect of anti-TPO and anti-Tg antibodies for breast cancer in this study and a previous study on the association of benign thyroid diseases and cancer (149)

6.3 Dietary interventions Diet has been shown to have a significant effect on mood disorders and also on the composition and functionality of the gut microbiome (236, 237)

& Brubaker, P