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The researchers compared exercise alone, exercise plus liraglutide, or liraglutide alone in people without diabetes

doi: 10.2337/dc19-0749 58 O'NeilPMBirkenfeldALMcGowanBMosenzonOPedersenSDWhartonSet al

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Adjusting Frequency During the Titration Phase Although the end goal is weekly injections, most patients begin with a lower dose and gradually increase over several weeks

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Patients who switched from semaglutide to orforglipron maintained a mean 79.3% of their body weight reduction compared with the placebo arm which maintained a mean 37.6% of their weight loss