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Safety & oversight vary

The short version: the combination appears safe for most patients, but your prescribing provider should know about both medications before you start either one

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

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Age is one factor, but lifestyle habits like smoking, drinking, and poor diet also play a big role