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doi: 10.1038/nature11450 21 BarNKoremTWeissbrodOZeeviDRothschildDLeviatanSet al

(2018) 172:40922.e21

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Rosenstock J, Wysham C, Frias JP, Kaneko S, Lee CJ, Fernandez Lando L, et al

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Eligible participants were aged 1875 years, had been diagnosed with type 2 diabetes for 6 months, had an HbA 1c value of 5386 mmol/mol (7.010.0%) and a BMI of 2550 kg/m 2 at screening and had been treated with a stable dose of metformin of 1000 mg/day (immediate or extended release) for 3 months before screening