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doi: 10.1038/s41392-021-00687-0 57 BaiXWangXLinTDongWGaoYJiPet al

394 Mice fed a high iron diet as well as those with inherited hemochromatosis (Hjv / and Smad4 Alb/Alb mice) all developed systemic iron overload due to decreased hepcidin expression in liver

Therapies enhancing GSH could become a cornerstone to reduce severity and fatal outcomes of inflammatory diseases and COVID-19 and increasing GSH levels may prevent and subdue these diseases

The accumulation of intracellular ROS caused by low levels of tert-butyl hydroperoxide can induce the activation of p53 and lead to cell death, which can be specifically inhibited by the ferroptosis inhibitor Fer-1 but cannot be inhibited by other kinds of cell death pathway inhibitors, indicating that the form of death is ferroptosis

The following adverse reactions may occur with undetermined frequency (frequency cannot be estimated on the basis of available data): - Allergic reaction - Acne - Pain at the injection site - Red coloration of urine (due to elimination of vitamin B12 in the urine)

Tsimberidou A, Thomas DA, OBrien S, Andreeff M , Kurzrock R, Keating M, Albitar M, Kantarjian HM, Giles FJ