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Metabolic research focus: Studied in obese rodent models for effects on fat oxidation, weight gain trends, and markers linked to fat breakdown and storage

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Vascular endothelial growth factor increases and induces the translocation of glucose transporter-1 to the cell membrane at the BBB, which promotes angiogenesis and decreases the expression of inter-endothelial tight junction proteins, such as occludin and zonula occludens-1 [73], thus causing BBB leakage