semaglutide making me hungry Still on Semaglutide? Understanding Why and What to Do Why am I still hungry

Semaglutide begins its biological action almost immediately after injection, as it circulates through your bloodstream and binds to GLP-1 receptors throughout your digestive tract and brain

This may lead to hot flashes, especially in individuals who are sensitive to temperature changes or have other underlying conditions that affect temperature regulation

If eating has become genuinely distressing, discuss dose reduction with your provider

Unlike caloric restriction, which triggers adaptive metabolic reprogramming, including enhanced autophagy and neuronal plasticity 69,70 , semaglutide primarily reduces food intake through appetite suppression 71

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