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The mechanism argument first: semaglutide binds to and activates GLP-1 receptors

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(2022) analyzed the Rotterdam cohort ( n = 1,054) with validation in the Amsterdam HELIUS cohort ( n = 1,539), identifying 13 microbial taxa associated with depressive symptoms, including Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, and Ruminococcaceae family members