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Preclinical murine studies have shown that triagonists, in comparison to dual-incretin co-agonists, more effectively reduced adipose tissue, hepatic steatosis, plasma cholesterol, and improved glucose tolerance while achieving a favorable energy balance by increasing energy expenditure and decreasing food intake

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Empagliflozin also has the benefits of reducing this obese patient's weight, BP, and HbA1c without the risks of hypoglycemia (this is a pro compared to secretagogues, TZDs, and insulin which tend to increase weight) but he should be counseled about the signs of ketoacidosis