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That follow-up trial, involving 536 obese adults over 24 weeks, failed to meet its primary efficacy endpoint, meaning the fat-loss effect seen at the smaller scale did not hold up in the pivotal study

In fact, GLP-1 medications are not approved for use during pregnancy

Jaramillo et al

Findlay J

More water means a lower concentration and a larger draw volume for the same research quantity

Regardless of starting body size or how much weight participants lost, semaglutide consistently improved heart health outcomessuggesting it may offer protective cardiovascular effects that extend beyond its impact on body weight