Ebersole BM, Zafereo ME , Hutcheson KA
Researchers have found that human proximal tubule epithelial cell lines exhibited distinct ultrastructural alterations indicative of pyroptosis when exposed to high glucose, and that the expression of TLR4, NLRP3, caspase-1, GSDMD-N, IL-1, and IL-18 are significantly upregulated (124)
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The encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles does not alter the well documented biocompatibility of PLGA as evident from similar cellular viability of MCF-7 cells upon exposure to empty PLGA nanoparticles or PLGA nanoparticles encapsulating DDA-GSH-AuNCs in a wide range of nanoparticle concentration (4500 g/mL) as shown in Fig
Dewilde WJM, Oirbans T, Verheugt FWA, et al