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Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)

Damaged hepatocytes may release massive amounts of cell contents, such as nuclear DNA fragments, mitochondrial DNA, high mobility group box-1 (HMGB1), and ATP

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Although injectable drug delivery bypasses the gastrointestinal tract, it remains associated with pain, infection risks, and reduced patient compliance