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The maximal concentration of buprenorphine in serum (C max ), t max (time to reach C max ), t (half-life) and AUC (area under the plasma concentration curve) were calculated with a non-compartmental model using the PK Solver add-in for Microsoft Office Excel

PMCID: PMC5816795.

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Briefly, under visualization with an operating microscope, 50 l of any one of the formulations described herein and varying concentrations of P407 are administered to the animals

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