NF-B is a key transcriptional regulator of inflammatory mediators and leads to, for example, increased expression of TNF-, IL-6, IL-8, E-selectin, VCAM-1, and ICAM-1 [166,167,168]
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Ultimately, PUFA-PE can play further oxidative roles under the catalysis of lipoxygenase (LOX) and eventually induce ferroptosis in cells 30
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Owing to the presence of the Ox-mtDNA autoantibody, mtDNA is potent antigen that stimulates autoantibody production in SLE (72), and NLRP3 signaling pathway (51)