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Early studies in the late 1990s, suggested that high circulating IGF1 concentrations are associated with an increasing risk of colorectal cancer 23, 73

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68 These effects may be particularly beneficial in obese patients with T2DM who are at elevated cardiovascular risk

A full list of covariates and their operational definitions is presented in Supplementary Table 3

Weight loss tends to accumulate slowly, roughly one to two pounds per week is typical at therapeutic doses, rather than appearing dramatically

These mechanisms contribute to the superior results seen with tirzepatide weight loss compared to other treatments