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Telomerase normally helps offset that loss, as outlined in this reference on telomerase and telomere maintenance

482, 2019 [55] K

A recent international study shows it may be possible that getting too little deep sleep prevents glymphatic clearance and can cause neurological diseases

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Atay S, Van Haren R, Niu J, Giodana S, Antonoff M, Hofstetter W, Mehran R, Rice D, Vaporciyan A, Walsh G, Roth J, Swisher SG , Sepesi B

Recent research published in eLife has documented cases where gray hairs have naturally repigmented, particularly when stress levels decreased