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This receptor has been reported to be expressed by colonic GLP-1-secreting enteroendocrine cells and pancreatic -and -cells (100, 101), with some controversy regarding the presence in murine islets (339)

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Saxenda is specifically indicated for use in adults with obesity (with a body mass index BMIof 30 kg/m2 or greater) or overweight adults (a BMI of 27 kg/m2 or greater) who also have weight-related health conditions such as hypertension (high blood pressure), high cholesterol, or obstructive sleep apnea

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