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In the case of the explanted heart, the heart failure was very severe (LVEF = 25%), whereas mice on the iron-rich diet had moderate cardiomyopathy (LVEF = 48%)

Dehydration accelerates this effect

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This article explains the trial-based dosing rationale, escalation schedules, influencing factors, side effects, and the current regulatory status in the UK

Association of body iron stores with low molecular weight iron and oxidant damage of human atherosclerotic plaques