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Developmental control of synaptic receptivity
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AD patients also display additional biomarkers including cerebrovascular pathology and vascular dysfunctions, decreases in cerebral blood flow, cerebrovascular reactivity, and neurovascular coupling, leading to brain deficits in oxygen and nutrient delivery [4,5]
On regulatory status, the picture is straightforward and important
Clinicians therefore need to know not only the half-life of the drug that they are prescribing but also what the half-life might be given the presence of one or more of these factors in the patient to whom the drug is being prescribed
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