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This typically requires BMI of 30 or higher (or 27 with comorbidities), absence of contraindications, willingness to attend regular study visits, and acceptance of randomization (you might receive placebo)

Additional risks specific to the bodybuilding context include: Cardiovascular strain: Increases in resting heart rate have been observed with GLP-1 receptor agonists as a class (as documented in the Summary of Product Characteristics for licensed agents such as semaglutide and tirzepatide)

In Phase 2 clinical trials, patients showed progressive, dose-dependent weight loss of up to 24.2% of body weight with a 12 mg weekly dose

Cardiovascular disease risk assessment and prevention BNF/NICE

An incentive P.B

M., & McAlister, F