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Combination therapies Tirzepatide: Combines GLP-1 and GIP receptor agonism for dual-action benefits

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While the inflammation-reducing and fibrosis-attenuating effects of glucagon agonism are less well-characterized, the reductions in hepatic inflammation parameters and fibrosis observed in preclinical models likely reflect secondary effects consequent to improved steatosis, rather than direct anti-inflammatory actions [21]

Once they are significantly diminished, a prolonged deficiency can lead to substantial damage, especially to the nervous system

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