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To maintain a steady, endogenous supply of cysteine for glutathione production, the body relies heavily on the transsulfuration pathway

Renal glutathione transport: Identification of carriers, physiological functions, and controversies

When it comes to glutathione, dosage determines outcome

The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation

And of those antioxidants, were talking about one specifically

The simplified 2D microenvironmentdevoid of a 3D matrix, vasculature, and key factors such as CPfurther leads to dysregulated copper transporter expression and non-physiological toxicity responses [252]