In some tissues, such as that of liver, heart, and kidney, mitochondrial glycerol-3-phosphate dehydrogenase (GPD2) is present in very low amounts, and the malate-aspartate shuttle is the dominant pathway for aerobic oxidation of cytosolic NADH
Monitor and adjust dosages under medical supervision
Both melphalan and chlorambucil are larger molecules than most of the compounds studied in this work, and they possess aromatic rings in their chains, which increases their hydrophobicity
BloodBrain Barrier, BloodCerebrospinal Fluid Barrier, and Neurovascular Unit The mammalian brain is separated from the general circulation system by the BBB, which is localized in the brain capillaries and pia-subarachnoid membranes, and the BCB localized in the choroid plexus of the brain ventricles
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