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Alternative medications include: TNF agents such etanercept (Enbrel), infliximab (Remicaide), or adalimumab (Humira) IL-17 agents such as secukinumab (Cosentyx) and ixekizumab (Taltz) Tofacitinib (Xeljanz) a JAK inhibitor (not approved by FDA yet but understudy) These biologic medications may alter the progression of disease by treating inflammation and preventing the development of fibrosis and then bone formation

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