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This aminoacid was shown to reduce depression scores in people with unipolar depression in methodologically limited studies, so further evidence is required in order to consider it as an adjunctive therapy (341)

Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior

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The metabolites cyclic 3-hydroxy melatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), which can reduce free radicals, are formed when MLT reacts directly with free radicals, including hydroxyl (OH ), superoxide (O 2 ), and reactive nitrogen species, such as nitric oxide (NO ) The hypothesis that MLT has a multifunctional role as a mitochondrial antioxidant is supported by numerous investigations [116,117,118]

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