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in vitro
Most gastroenterologists agree that during acute inflammation or recent flare-ups, starting GLP-1 therapy should be postponed until disease remission is confirmed
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To prolong these effects therapeutically, GLP-1 RAs were designed to resist rapid degradation, allowing these medications to remain active in the human bloodstream for days
Nuclear factor E2-related factor 2 (Nrf2), a key transcription factor and endogenous antioxidant, maintains cellular metabolic homeostasis, redox state, and protein homeostasis
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