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Treatment discontinuation due to adverse events ranged from 5.3% to 10.3% across orforglipron dose groups compared with 2.7% for placebo

Long-term human safety data beyond 6 weeks is lacking, leading to conservative recommendations for cycling

Because they slow gastric emptying, they are cautioned in severe GI disease such as gastroparesis, and they are generally avoided in pregnancy and end-stage renal disease

It is a metabolic engine that drives inflammation, insulin resistance, and cardiovascular risk

Airline restrictions, however, can be confusing

The GLORY-1 trial used 4 mg and 6 mg over 48 weeks, while GLORY-2 tested 9 mg over 60 weeks