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More worrisome, large doses of berberine may cause diarrhea, stomach upset, and nausea

Participants who titrated from the lowest starting dose (2mg) generally achieved slightly better outcomes at the 12mg target

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"I think one of the things that needs to be understood is that a GLP-1 agonist, whether it's for weight loss or diabetes, it is meant to be on for a while, this is a long-term therapy

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