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GLP-1 RAs and SGLT-2 inhibitors both have beneficial weight effects that should inform drug selection
29 These results suggests that the reported negative retinopathy outcomes observed in some studies may not be specific to the GLP-1/GIP agonists, but rather scenarios where their use resulted in larger drops in A1c
When adding GLP-1-R-Antagonist Exendin(9-36), Cantini et al
Comparison Table: Retatrutide vs Tirzepatide Side Effects and Safety Profile Common Side Effects (Both Medications) Both tirzepatide and retatrutide share a similar gastrointestinal side effect profile, which is characteristic of incretin-based therapies: Nausea (most common, typically transient) Diarrhea Constipation Vomiting Decreased appetite Abdominal discomfort Fatigue These effects are generally mild to moderate and tend to diminish as the body adjusts to the medication, particularly when doses are titrated gradually
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