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In January, the Trump administration debuted TrumpRx.gov where consumers can purchase the medications at a discount if they are not eligible to participate in the GLP-1 bridge program

Clinical rigor is not uniform across all providers

Nausea may be more pronounced at the beginning of treatment and may lessen as the body adjusts

These high circulating FFAs, alongside inflammatory adipokines released by dysfunctional fat tissue, impair insulin signaling and develop systemic insulin resistance

NICE recommends continuing GLP-1 therapy only if HbA1c reduces by at least 11 mmol/mol and weight decreases by at least 3% at six months

Furthermore, there may be concerns regarding the long-term safety profile and uncommon adverse effects associated with GLP-1 receptor agonists, which may limit their use in specific patient populations