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Intriguingly, MM cells without mutations in BRAF or NRAS mutations tend to exhibit CCND1 or CDK4 amplification (122), suggesting that copy number variations of cell cycle regulatory genes act as an alternative driver and can substitute for BRAF or NRAS mediated proliferation signaling pathway activation

Predictions of Protein Structure and the Principles of Protein Conformation

The PPAR- and PPAR- pathways, as important starting molecular factors associated with PFAS, serve essential functions in maintaining the balance of metabolic components, including carbohydrates, fats, and proteins