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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling
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A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N -acetyl- meta -aminophenol (AMAP)
doi: 10.1016/j.neubiorev.2017.06.001 138 DumanRSAghajanianGKSanacoraGKrystalJH
45 DingJ.ZhangJ.WangX.ZhangL.JiangS.YuanY.et al (2017)
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