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Clinical trial data have generated significant interest in retatrutide because of its substantial weight-loss results, including Phase 3 findings showing average body weight reductions of more than 30% at the highest studied dose over 80 weeks

If persistent, reduce dose

It names pre-existing mitochondrial disease, severe renal disease, active malignancy and autoimmune pancreatitis as conditions that should rule out the combination absent specialist sign-off

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