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Substituting histidine at position 2 with other residues dramatically reduces copper-binding affinity and alters the complex's properties

But these technologies are currently specific to certain peptides and not broadly applicable

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Full description Cagrilintide is a long-acting analog of human amylin hormone, developed by Novo Nordisk as a key component of the CagriSema project (cagrilintide + semaglutide)