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[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Bonanomi L., Gazzaniga A

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From an immunological perspective, these associations arise from a breakdown in self-tolerance mediated by overlapping T-cell and B-cell autoreactivity, shared cytokine pathways (e.g., IFN-, IL-18), and common antigen-presenting HLA alleles

Tirzepatide escalates from 2.5mg 5mg 7.5mg 10mg 12.5mg 15mg in 4-week steps (6 levels)