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Ceramide generation was a critical component of Fas receptor-induced eryptosis, whereas therapy with natural organosulfur compounds inhibited the apoptotic death of erythrocytes by antagonizing oxidative stress and the Gardos channel that led to suppression of ceramide-initiated Fas aggregation in lipid rafts of these erythrocytes

How Does This Relate to Immune System Support

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These metabolites act through the Vitamin D receptor (VDR) in adjacent cells to finely modulate barrier integrity, immune tolerance, and antioxidant responses

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doi: 10.1016/j.molbiopara.2008.09.005