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Two major clinical trials are the basis for most of what's known about these medications' weight-management effects: STEP 1 (68-week randomized study, adults without diabetes): semaglutide 2.4 mg produced an average loss of roughly 15% of body weight, versus about 2.4% with placebo, alongside a reduced-calorie diet and increased physical activity

While some telehealth companies have completely ceased offering tirzepatide and semaglutide, others have adjusted their offerings so that they are either in oral formats (like dissolving tablets) that are different than injectables, in custom dosages, or sold with additives like vitamin B