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Niacinamide improves skin tone and barrier function 1

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Swiss researchers Marcel Monnier and Guido Schoenenberger first isolated this compound in 1977 while studying the blood of rabbits during electrically-induced sleep states

The most common side effects were transient and mild: injection site reactions, headache, and nausea

Chou, W.Z

Upcoming USP guideline changes set to go into effect November 2023 now delineate the allowed BUD for aqueous dosage forms (in the absence of an acceptable study as outlined by the guideline) not based on route of administration but based on preservative status, allowing up to 14 days for unpreserved aqueous preparations and up to 35 days for preserved aqueous preparations.2 In light of a new emphasis on preservative status, it is essential to understand how preservatives work and which may be appropriate for a given preparation based on characteristics such as route of administration, excipients, and chemical characteristics such as a preparations pH