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Biomarker Verification To verify target engagement in humans without direct hippocampal transcriptomics, peripheral proxy markers must be monitored: For Intranasal GHK-Cu (Metabolic Dampening): Monitor systemic proxies for mTOR suppression and mitochondrial load

Zuhra et al., 2020

Final concentrations of K105X and E170X mutants were 10 nM to 1.5 M and 520 nM, respectively

Galon and Bruni, 2020)

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SU11274 inhibits cell viability in c-Met-expressing non-small cell lung cancer (NSCLC) cells with IC 50 values of 0.84.4 M, and abrogates HGF-induced phosphorylation of c-Met and its downstream signaling [64, 67]