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PLoS One 7 , e31494, doi: 10.1371/journal.pone.0031494 (2012)

To protect tissue health and minimize irritation, rotate between sites with each injection and maintain at least one to two inches of distance from previous injection points

In acute wounds, the immune response is generally well-regulated, allowing for a relatively quick resolution of inflammation and the restoration of tissue integrity

Light pressure is fine

The peptide also increases hyaluronic acid synthesis by 60% in cell culture models, contributing to improved hydration markers characteristic of younger tissue